What Is KPV?
KPV stands for its amino acid sequence: Lysine-Proline-Valine. It is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH), a naturally occurring peptide hormone produced in the pituitary and peripheral tissues. The full α-MSH molecule has broad anti-inflammatory effects; KPV is the smallest fragment that retains this activity.
Its small size (three amino acids) makes it stable enough for oral delivery to the gut — unlike larger peptides that are broken down before they reach their target. This gives KPV an advantage for intestinal applications over injection-only compounds.
Primary Applications
- Inflammatory bowel disease (IBD): Crohn's disease and ulcerative colitis — reduces mucosal inflammation
- Leaky gut / intestinal permeability: Promotes tight junction integrity and epithelial barrier repair
- Post-infectious gut dysfunction: After viral or bacterial GI illness that leaves chronic inflammation
- Systemic inflammation: Autoimmune flares, chronic inflammatory conditions
- Wound healing: Anti-inflammatory effect accelerates skin and mucosal repair
Gut Peptide Stack: KPV + BPC-157
KPV
Suppresses NF-κB and inflammatory cytokines. Directly calms immune overactivation in gut tissue. Best taken orally for intestinal effects.
BPC-157
Promotes angiogenesis and structural repair of the mucosal lining. Works through different pathways — addresses the healing side rather than just inflammation suppression.
Combined use is common in clinical practice for IBD and gut permeability. Discuss with your physician for a personalized protocol.
Cost in Tennessee
KPV capsules run $80–150/month. Injectable KPV is comparable. Consultation fees are $99–199. See our full cost guide.